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. Author manuscript; available in PMC: 2012 Dec 13.
Published in final edited form as: J Med Chem. 2009 Aug 27;52(16):5164–5175. doi: 10.1021/jm900473p

Figure 2.

Figure 2

Comparison of the in vitro metabolic stability for 1 (open circle), 2 (open triangle), 5 (crossing) and 6 (filled circle) incubated in rat plasma at 37°C. Calculated half lives of peptide derivatives (T1/2) were 4.8 h for 1 and > 6 h for 2, 5 and 6. 70 ± 9 % of 6 was found intact after 24 h incubation. The samples were tested in three independent experiments (n = 3) and the mean values were used for the analysis with the SD. Statistical significance was determined by Kruskal-Wallis test followed by Tukey’s test. Asterisks denote significant differences (* p < 0.05; ** p < 0.01; *** p < 0.001).