. Author manuscript; available in PMC: 2012 Dec 13.

Published in final edited form as: J Med Chem. 2009 Aug 27;52(16):5164–5175. doi: 10.1021/jm900473p

Table 2.

Opioid agonist functional activities in [³⁵S]GTPγS binding assays

No	hDOR^a			rMOR^a

	LogEC₅₀^b	EC₅₀ (nM)^c	Emax (%)^d	LogEC₅₀^b	EC₅₀ (nM)^c	Emax (%)^d
1^e	−8.07 ± 0.11	8.6	60 ± 2	−8.16 ± 0.17	7.0	51 ± 3
2	−8.30 ± 0.09	5.0	120 ± 3	−7.74 ± 0.14	18	66 ± 3
3	−7.29 ± 0.12	52	49 ± 2	−6.76 ± 0.31	180	24 ± 3
4	−7.56 ± 0.14	51	130 ± 3	−6.42 ± 0.19	380	81 ± 6
5	−8.10 ± 0.08	7.9	64 ± 2	−7.75 ± 0.23	18	38 ± 3
6	−7.56 ± 0.27	28	49 ± 3	−8.21 ± 0.24	6.2	50 ± 3
Biphalin	−8.95 ± 0.17	1.1	83
DPDPE	−8.80 ± 0.25	1.6	69
DAMGO				−7.44 ± 0.19	37	150

Expressed from HN9.10 cell.

The log EC₅₀ ± standard error are logarithmic values determined from the non-linear regression analysis of data collected from at least two independent experiments performed in duplicate.

Anti-logarithmic value of the respective EC₅₀.

[Total bound − Basal]/[Basal − Non-specific] × 100

Reference.²⁰