Table 1. Comparison of model properties to in vitro data.
| Model | Guinea pig [13] [14] [29] | Mouse (n = 6) | |
| STO frequency | 6–8 Hz | 4–10 Hz | 3–10 Hz (6±2 Hz) |
| STO amplitude | 1–10 mV (default: 6.4 mV)a | 5–10 mV | 2–6 mV (5±3 mV) |
| Spike ADP amplitude | 28±3 mV (20–32 mV) | 49±8 mV | 30±5 mV (23–38 mV) |
| Spike ADP duration | 10–16 ms | 20–25 msb | 6–12 ms (7±0.4 ms) |
| Spike AHP duration | 139–241 ms (191±31 ms) | Up to 250 ms | 90–165 ms (125.4±30 ms) |
a
Intrinsic STO amplitude based on variable T-type calcium conductance value ranging from 0.55 mS/cm2 to 0.9 mS/cm2. Default conductance value was 0.7 mS/cm2.
b
Total calcium depolarization, including time prior to and during primary sodium spike. The actual spike ADP duration would thus be shorter.
Model properties compared to results from experiments conducted in vitro on guinea pig slice preparations as found in literature and from in vitro experiments conducted in our lab on mouse slice preparations. All values are either the observed range of values or the mean ± SD. The model generalizes the properties of IO neurons well.