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. 2012 Dec 15;23(24):4739–4750. doi: 10.1091/mbc.E12-04-0310

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© 2012 Saito et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 2: — FilGAP is required for MAT. (A) Patterns of morphological change during 24-h culture. Migrating MDA-MB-231 cells were monitored by time-lapse video microscopy for 24 h after seeding on collagen gels (see Material and Methods) and categorized as having no plasticity of migration mode (a) or undergoing AMT (b + b′). (B) The proportion of patterns categorized in (A). The data are the mean ± SD of three independent experiments (n > 50 cells counted for each experiment). Among cells undergoing AMT, the percentage of cells that again converted to the round/amoeboid morphology during 24-h culture was also calculated (MAT: b′ in (A)). (C) Frequency of AMT during 24-h culture in each cell that undergoes AMT. **, p < 0.01; *, p < 0.05. Statistical significance was determined by Student's t test.