Figure 3. Ranolazine (RAN) inhibited the increase in I _Na.L caused by 300 µM H₂O₂.

A. 3, 6 and 9 µM ranolazine decreased the amplitudes of the increased I _Na.L induced by 300 µM H₂O₂ in a concentration dependent manner. B. The I-V relationships of I _Na.L after the sequential application of H₂O₂ alone, H₂O₂ plus 3, 6 and 9 µM ranolazine. C. the inhibition amounts of 3, 6 and 9 µM ranolazine on △I _Na.L induced by 300 µM H₂O₂. Values are expressed as mean ± SD, n = 8 cells/group. ^*P<0.01 versus H₂O₂ group; ^#P<0.01, ^##P<0.05 versus 3 µM ranolazine group; ^§P<0.01, ^§§P<0.05 versus 6 µM ranolazine group.