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. 2012 Dec 13;7(12):e51140. doi: 10.1371/journal.pone.0051140

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© 2012 Wang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A, mouse kidney injuries caused by unilateral (SS) or bilateral (DS) I/R. B, BUN assay of mouse kidney injury by I/R. Note that the BUN assay was able to detect kidney injury caused by DS I/R but not that caused by SS I/R. C–D, significant elevation of the urinary miR-10a (C) and miR-30d (D) levels in mice with either SS I/R or DS I/R. E, no alteration of miR-16 in mouse urine after I/R-mediated kidney injury. The data are presented as means ± SEM for six independent experiments; three mice were used in each experiment. *, p<0.05. **, p<0.01.