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. 2012 Sep 11;18(1):1320–1326. doi: 10.2119/molmed.2012.00244

Figure 1.

Figure 1

Design (A) and pharmacodynamic results of study 1 (B, C): effect of saline and NTX pretreatment on morphine-(MOR) or saline-induced changes in TWL in CD-1 mice. (A) Timing of TWL measurements and drug injections. (B) Saline pretreatment caused morphine-induced analgesia. Saline/MOR versus NTX/saline: P < 0.001; *P < 0.001 versus baseline. (C) NTX pretreatment caused morphine-induced hyperalgesia. The combination NTX/saline had no effect on the measured latencies. NTX/MOR versus NTX/saline: P < 0.001; *P < 0.001 versus baseline. Values are means ± SEM.