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. Author manuscript; available in PMC: 2013 Jun 13.
Published in final edited form as: Nature. 2012 Nov 21;492(7428):261–265. doi: 10.1038/nature11654

Figure 1. Age-induced mitochondrial dysfunction is suppressed by VMA1 overexpression.

Figure 1

Age (divisions) in lower panels of all figures represents exact age for young cells (0–5) and median age for older cells as determined by calcofluor staining of bud scars. n = 30 for all timepoints in all figures. A representative image is shown for each timepoint in all figures. a, Mitochondrial morphology in aged cells expressing the mitochondrial outer membrane protein Tom70-GFP. b, Mitochondrial membrane potential as indicated by DiOC6 staining of aged Tom70-mCherry wild-type (WT) and VMA1 overexpressing cells incubated with or without 500 nM concA for 2 h. Note that DiOC6 stains the plasma membrane of aged cells. M = mother cell.