Skip to main content
. Author manuscript; available in PMC: 2013 Jun 13.
Published in final edited form as: Nature. 2012 Nov 21;492(7428):261–265. doi: 10.1038/nature11654

Figure 3. Reduced vacuolar acidity causes mitochondrial dysfunction by disrupting amino acid homeostasis.

Figure 3

DiOC6 staining of aged Tom70-mCherry WT, (a) AVT1 overexpressing and (b) avt1Δ cells. c, Quinacrine and DiOC6 staining of aged WT and avt1Δ cells overexpressing VMA1. d, RLS of wild-type (WT), avt1Δ, and AVT1 overexpressing cells by micromanipulation. Median lifespan is indicated. p = 0.0376 (WT vs AVT1 OE), p = 0.0045 (WT vs avt1Δ), Wilcoxon rank-sum test. n = 32 for WT, 32 for AVT1 OE, and 31 for avt1Δ.