Table 2.

ABPM variables associated with advanced aortic valve calcification (score ≥4mm) -Multivariate analysis

BP variables	Advanced calcification
	Model 1			Model 2			Model 3
	OR	95%CI	P	OR	95%CI	P	OR	95%CI	P
Office SBP	1.03	0.79–1.34	0.85	1.00	0.77–1.32	0.98	1.08	0.82–1.43	0.59
Office DBP	1.18	0.91–1.53	0.22	1.17	0.90–1.52	0.24	1.21	0.91–1.59	0.19
Mean 24 h SBP	1.24	0.96–1.60	0.11	1.24	0.96–1.61	0.10	1.24	0.94–1.62	0.12
Mean 24 hr DBP	1.29	0.99–1.67	0.06	1.29	0.99–1.68	0.06	1.42	1.06–1.89	0.02
Mean awake SBP	1.27	0.99–1.63	0.06	1.28	1.00–1.65	0.053	1.30	1.00–1.69	0.053
Mean awake DBP	1.31	1.01–1.71	0.04	1.32	1.01–1.72	0.04	1.45	1.09–1.94	0.01
Mean asleep SBP	1.21	0.93–1.57	0.15	1.22	0.94–1.58	0.14	1.23	0.94–1.62	0.13
Mean asleep DBP	1.34	1.04–1.72	0.02	1.35	1.04–1.74	0.02	1.49	1.13–1.97	0.005
SBP awake variability	1.02	0.79–1.31	0.91	1.02	0.79–1.32	0.87	1.03	0.78–1.35	0.85
SBP awake variability †	0.94	0.72–1.23	0.66	0.95	0.73–1.24	0.69	0.95	0.71–1.26	0.72
DBP awake variability	0.93	0.71–1.22	0.61	0.92	0.70–1.21	0.54	0.96	0.72–1.29	0.81
DBP awake variability †	0.84	0.63–1.12	0.24	0.83	0.62–1.11	0.21	0.86	0.63–1.17	0.32
SBP asleep variability	1.01	0.79–1.30	0.94	1.02	0.79–1.31	0.89	0.98	0.74–1.28	0.86
SBP asleep variability †	0.96	0.74–1.25	0.76	0.97	0.74–1.25	0.80	0.92	0.70–1.22	0.56
DBP asleep variability	0.96	0.75–1.22	0.71	0.96	0.75–1.22	0.74	0.99	0.76–1.30	0.95
DBP asleep variability †	0.89	0.69–1.14	0.36	0.89	0.69–1.14	0.35	0.90	0.68–1.19	0.47
SBP nocturnal decline	1.01	0.97–1.04	0.80	1.01	0.97–1.04	0.78	1.00	0.96–1.04	0.94
SBP nocturnal decline ‡	1.01	0.97–1.05	0.69	1.01	0.97–1.05	0.68	1.00	0.97–1.05	0.83
DBP nocturnal decline	0.98	0.95–1.01	0.20	0.98	0.95–1.01	0.20	0.97	0.94–1.01	0.11
DBP nocturnal decline ‡	0.98	0.95–1.01	0.23	0.98	0.95–1.01	0.22	0.98	0.94–1.01	0.15
Normal dipping status	0.87	0.48–1.58	0.64	0.89	0.49–1.61	0.69	0.79	0.41–1.51	0.47

Each row is a separate analysis;

Model 1: adjusts for age, male sex, cigarette smoking, hypercholesterolemia, diabetes mellitus, hypertension, serum creatinine, and the presence of aortic insufficiency.

Model 2: as in model 1 plus anti-hypertensive medication use and anti-hypertensive medication classes.

Model 3: as in model 2 plus anti-hypercholesterolemic medication use. All odds ratios are for 1 standard deviation change in the variable.

^† In addition to the general adjustments, this analysis was further adjusted for awake/asleep mean systolic/diastolic BP.

^‡ In addition to the general adjustments, this analysis was further adjusted for 24-hour BP.