Skip to main content
. Author manuscript; available in PMC: 2013 Dec 13.
Published in final edited form as: J Med Chem. 2012 Nov 27;55(23):10729–10734. doi: 10.1021/jm301468k

Figure 2.

Figure 2

Chemical synthesis and characterization of cyclotide MCo-CVX-5c. A. Analytical HPLC traces of the linear thioester precursor, GSH-induced cyclization/folding crude after 96 h and purified cyclotide. An arrow indicates the desired peptide. B. ES-MS characterization of pure MCo-CVX-5c. The expected average molecular weight is shown in parenthesis. C. Chemical shifts differences of the backbone, NH and Hα protons between the common sequence (residues 1 through 29) of MCoTI-I24, 25 and MCo-CVX-5c (Table S2).