Table 1:
Serum markers, HBV genotypes/ subgenotypes, A1762T/G1764A mutations in 466 patients with chronic HBV infection
| Clinical parameters | CHB (n=160) | LC (n=150) | HCC (n=156) | Pa | Pb | Pc |
|---|---|---|---|---|---|---|
| ALT (U/L) | 133.62±96.37 | 98.76±66.08 | 75.38±51.69 | 0.010 | 0.003 | 0.016 |
| AST (U/L) | 48.32±36.35 | 75.18±60.27 | 125.20±66.51 | 0.001 | <0.0001 | 0.002 |
| TBIL (μmol/L) | 48.39±23.42 | 79.83±46.40 | 29.12±16.70 | 0.001 | 0.004 | <0.0001 |
| Platelet count (109/L) | 12.73±6.19 | 6.62±2.58 | 10.93±5.47 | <0.0001 | 0.007 | <0.0001 |
| HBeAg (+) | 94 (58.75) | 76 (50.67) | 76 (48.72) | 0.153 | 0.074 | 0.733 |
| AFP (ng/mL) | 12.1±4.8 | 47.9±16.2 | 942.3±426.4 | 0.004 | <0.0001 | 0.002 |
| HBV-DNA (log10copies/mL) | 5.42±1.42 | 5.86±1.37 | 5.93±1.02 | 0.006 | 0.003 | 0.612 |
| Genotypes / subgenotypes | ||||||
| B | 70 (43.75) | 42 (28.0) | 45 (28.85) | 0.006 | 0.005 | 0.898 |
| B1 | 0(0.0) | 0(0.0) | 0(0.0) | |||
| B2 | 70 (43.75) | 42 (28.0) | 45 (28.85) | 0.006 | 0.005 | 0.898 |
| C | 85 (53.13) | 105 (70.0) | 108 (69.23) | 0.002 | 0.003 | 0.884 |
| C1 | 2 (1.25) | 2 (1.33) | 1 (0.64) | |||
| C2 | 83 (51.88) | 103 (68.67) | 107 (68.59) | 0.003 | 0.002 | 0.988 |
| Genotype mixture | ||||||
| B/C | 5 (3.13) | 3 (2.0) | 3 (1.92) | |||
| A1762T/G1764A mutations | 66 (41.25) | 86 (57.33) | 92 (58.97) | 0.005 | 0.002 | 0.771 |
Data was presented as mean ± standard deviation or number (%).
a,
LC vs. CHB;
b,
HCC vs. CHB;
c,
HCC vs. LC.
P values for HBV subgenotype C1 and genotype mixture were not shown because of small sample size.
CHB, chronic hepatitis B; LC, liver cirrhosis; HCC, hepatocellular carcinoma; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TBIL, total bilirubin; HBeAg, HBV e antigen; AFP, α fetoprotein