Table 1.
Caffeine effects on biometric parameters of the animals and prostatic lobes
| Experimental groups | ||
|---|---|---|
| Parameters | CT | CF |
| Body weight in the 1st week (g) | 128.31 ± 9.8 | 130.58 ± 10.2 |
| Body weight in the 10th week (g) | 356.75 ± 11.2 | 373.92 ± 17.8 |
| Body weight in the 20th week (g) | 487.95 ± 36.65 | 518.06 ± 49.99 |
| Testosterone (ng/ml) – 20th week | 1.34 ± 0.72 | 2.26 ± 0.44* |
| Dihydrotestosterone (ng/ml) – 20th week | 0.21 ± 0.03 | 0.33 ± 0.08* |
| Water intake in the 1st week (ml/day) | 28.9 ± 2.3 | 28.9 ± 2.8 |
| Water intake in the 10th week (ml/day) | 36.9 ± 4.3 | 38.7 ± 4.8 |
| Water intake in the 20th week (ml/day) | 39.38 ± 6.78 | 42.15 ± 6.57 |
| VP | ||
| Absolute weight (g) | 0.57 ± 0.09 | 0.71 ± 0.09* |
| Relative weight | 0.11 ± 0.01 | 0.14 ± 0.02* |
| Epithelium height (μm) | 26.06 ± 2.85 | 24.39 ± 3.95* |
| Focal epithelial hyperplasia | 0/12 | 5/12 |
| Diffuse epithelial and stromal hyperplasia | 0/12 | 3/12 |
| Collagen fibers volume (mm3) | 5.37 ± 1.85 | 6.06 ± 2.26 |
| DLP | ||
| Absolute weight (g) | 0.46 ± 0.10 | 0.50 ± 0.09 |
| Relative weight | 0.10 ± 0.02 | 0.10 ± 0.02 |
| DP | ||
| Epithelium height (μm) | 14.10 ± 2.73 | 12.67 ± 2.76 |
| Collagen fibers volume (mm3) | 4.94 ± 2.5 | 4.66 ± 0.77 |
CT, control group; CF, caffeine-treated group; VP, ventra prostatic lobe; DLP, dorsolateral prostatic lobe; DP, dorsal prostatic lobe.
Statistical analyses based on Student's t-test. Values represent mean ± SD.
*
P < 0.05 when compared with the CT group.