Table 3.

Posttranslational modifications in NETs.

Source of NETs	Stimulation	Enriched PTMs found in NETs			Affected PTMs in NETs
		Acetylation	Citrullination	Methylation	Acetylation	Citrullination	Methylation
Human peripheral	Hydrogen peroxide	H4K5Ac	H3Cit(2,18,17)	H4K20Me1/2/3	H3K9Ac
neutrophils		H4K16Ac	H4Cit3
ATRA/GM-CSF	Hydrogen peroxide		H3Cit(2,8,17)	H3K9Me2	H2BK12Ac		H3K36Me2
differentiated murine	Ionomycin		H3Cit26	H3K27Me1/2/3	H3K9Ac		H4K20Me2
EPRO cells	LPS		H4Cit3	H4K20Me1/2/3	H3K27Ac
	PMA				H4K16Ac
	TNF				H3R17Me2(a)
					H4R3Me2(s)
ATRA differentiated	Hydrogen peroxide			H3K27Me1/2/3	H2BK12Ac	H3Cit(2,8,17)	H3K36Me2
human leukemia	LPS				H3K9Ac	H3Cit26	H4K20Me2
HL-60 cells	TNF				H3K27Ac		H3R2Me2(a)
							H3R17Me2(a)
							H4R3Me2(s)

Abbreviations

K

lysine

R

arginine

Me

methyl

Ac

acetyl

Cit

citrulline

(a)

asymmetric

(s)

symmetric

TNF

tumor necrosis factor

EPRO

early promyelocyticcell line

ATRA

all-trans retinoic acid

PMA

phorbol 12-myristate 13-acetate

LPS

lipopolysaccharide.