Table 1.

Pharmacokinetic studies of fluconazole in premature infants

Study	N	GA (weeks)	Dose (mg/kg)	BW (g)	t½ (hr)	CL (L/kg/hr)	V (L)	Cmax (µg/mL)	AUC (µg*hr/L)
Saxen et al.24	12	25–29	6	750–1100	5–89	0.011–0.031	1.18–2.25	3.7 – 17.8	not reported
Nahata et al.26	6	26–40	6	not reported	not reported	0.010 –0.017	not reported	6 – 13.5	340–636
Wenzl et al.27	3	24–29	4.5–6	not reported	35	not reported	1.43	6.8 – 11.9	175.4
Wade et al.42, 28	55	23–40	3–12	451–7125	not reported	*	*	not reported	not reported

N = Number of subjects

GA = Gestational age (weeks)

BW = Birth weight (g)

t½ = Terminal half life of elimination (hours)

CL = Clearance (ml/min/kg)

V = Volume of distribution (L/kg)

Cmax = Maximum serum concentration (µg/ml)

AUC = area under the curve (ug*hr/ml)

^*These results were reported as a formula, based on the population PK model, to calculate PK parameters