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. 2012 Dec 14;6:85. doi: 10.3389/fnbeh.2012.00085

Figure 3.

Figure 3

Mean fEPSP values of initial 30 min and last 30 min of recordings of potentiation after EE. Bar charts show the mean fEPSP values recorded either in the first 30 min immediately after application of HFS, or the last 30 min (ca. 24 h after HFS) in mice stimulated with either one application of 50 pulses at 100 Hz, or two applications of 50 pulses at 100 Hz. LTP elicited with the stronger protocol (2 × 50 pulses) lasts for over 24 h but does not respond to EE (compared to non-enriched controls). LTP elicited with the weaker protocol (1 × 50 pulses) is no longer present 24 h after HFS in controls. However, the initial 14 day exposure to EE (1st EE) enhances the magnitude of the first 30 min of E-LTP. Re-exposure to EE (2nd EE) 6 weeks after 1st EE results in a significant prolongation of late (L-)LTP in EE-treated mice compared to controls that is evident 24 h after HFS. The reference baseline is represented by a black bar (100%). Asterisk denotes significant effect.