Table 2.
Comparison of pharmacokinetic parameters between traditional decoction (TD) and concentrated powder (CP) of GQT.
| Metabolites | Dosage form |
C
max
(nmol/mL) |
AUC0–4320
(nmol·min/mL) |
MRT0–4320
(min) |
|---|---|---|---|---|
| Daidzein S/G | TD | 8.9 ± 1.2 | 13669.7 ± 1704.7a | 1647.4 ± 103.3 |
| CP | 7.0 ± 0.9 | 9720.4 ± 853.4b
(−28.9%) |
1842.7 ± 100.8 | |
|
| ||||
| Baicalein S/G | TD | 4.7 ± 1.3 | 5445.1 ± 1212.9 | 1513.7 ± 209.8 |
| CP | 3.2 ± 0.5 | 3949.7 ± 666.2 | 1451.3 ± 85.2 | |
|
| ||||
| Wogonin S/G | TD | 1.7 ± 0.4 | 2314.3 ± 495.4 | 1409.7 ± 163.9 |
| CP | 1.1 ± 0.3 | 1816.2 ± 319.7 | 1476.5 ± 100.9 | |
Data expressed as mean ± S.E.
Means in a column without a common superscript difference, P < 0.05.
C max: peak serum level.
AUC0–4320: area under the serum concentration-time curve to 4320 min.
MRT: mean residence time.