Table 1.
Mean (± SEM) number of responses for all six FR20 and FI-240 sec experiments
FR20 | ||||||
Veh | 5.0 mg/kg | 10.0 mg/kg | 20.0 mg/kg | 40.0 mg/kg | ||
Caffeine | Mean | 3181.3 | 3259.6 | 2630.3 | 2156.5 | 1493.8 |
SEM | 249.9 | 204.6 | 162.5 | 181.5 | 267.4 | |
Veh | 5.0 mg/kg | 10.0 mg/kg | 20.0 mg/kg | 40.0 mg/kg | ||
Theophylline | Mean | 2867.4 | 3114.6 | 3070.6 | 2540.5 | 1416.5 |
SEM | 131.2 | 186.4 | 234.0 | 250.8 | 159.1 | |
Veh | 1.0 mg/kg | 2.0 mg/kg | 4.0 mg/kg | 8.0 mg/kg | ||
MSX-3 | Mean | 3363.88 | 3271.88 | 3319.75 | 3458.38 | 3384.50 |
SEM | 182.91 | 128.79 | 90.61 | 114.12 | 97.65 | |
Veh | 0.125 mg/kg | 0.25 mg/kg | 0.5 mg/kg | 1.0 mg/kg | ||
Istradefylline | Mean | 3652.6 | 3832.0 | 4197.1 | 3921.4 | 3766.4 |
SEM | 331.6 | 317.2 | 271.8 | 247.3 | 264.2 | |
Veh | 0.1875 mg/kg | 0.375 mg/kg | 0.75 mg/kg | 1.5 mg/kg | ||
DPCPX | Mean | 3263.0 | 3154.0 | 3144.5 | 2687.9 | 2724.6 |
SEM | 161.3 | 180.7 | 217.2 | 352.7 | 103.9 | |
Veh | 1.5 mg/kg | 3.0 mg/kg | 6.0 mg/kg | 12.0 mg/kg | ||
CPT | Mean | 4268.0 | 4404.7 | 3908.3 | 4470.3 | 4366.7 |
SEM | 333.5 | 244.9 | 264.6 | 205.6 | 281.9 | |
FI-240 sec | ||||||
Veh | 5.0 mg/kg | 10.0 mg/kg | 20.0 mg/kg | 40.0 mg/kg | ||
Caffeine | Mean | 120.6 | 190.9 | 207.6 | 225.1 | 103.6 |
SEM | 17.8 | 22.8 | 21.8 | 17.7 | 13.9 | |
Veh | 5.0 mg/kg | 10.0 mg/kg | 20.0 mg/kg | 40.0 mg/kg | ||
Theophylline | Mean | 97.9 | 130.9 | 179.1 | 186.3 | 179.4 |
SEM | 12.8 | 10.0 | 17.7 | 20.7 | 28.5 | |
Veh | 1.0 mg/kg | 2.0 mg/kg | 4.0 mg/kg | 8.0 mg/kg | ||
MSX-3 | Mean | 82.4 | 93.3 | 162.3 | 129.9 | 69.1 |
SEM | 15.4 | 21.3 | 26.2 | 18.4 | 11.2 | |
Veh | 0.125 mg/kg | 0.25 mg/kg | 0.5 mg/kg | 1.0 mg/kg | ||
Istradefylline | Mean | 80.1 | 101.4 | 134.8 | 150.6 | 113.5 |
SEM | 13.4 | 17.5 | 26.6 | 28.4 | 14.4 | |
Veh | 0.1875 mg/kg | 0.375 mg/kg | 0.75 mg/kg | 1.5 mg/kg | ||
DPCPX | Mean | 127.3 | 97.3 | 120.3 | 101.9 | 95.9 |
SEM | 34.1 | 24.2 | 25.7 | 23.5 | 18.6 | |
Veh | 1.5 mg/kg | 3.0 mg/kg | 6.0 mg/kg | 12.0 mg/kg | ||
CPT | Mean | 82.4 | 63.1 | 83.4 | 69.3 | 95.6 |
SEM | 16.9 | 16.1 | 14.5 | 12.4 | 11.3 |