Figure 5.

Transcription factors that regulate a greater number of target genes exhibit less total information content in their binding motifs, in both S. cerevisiae (116 factors) and E. coli (60 factors). This empirical relationship is predicted by the stable region under our model, as we vary the number of true targets. Lines denote analytic equations (Equations 4 and 5), and arrows indicate the direction of selection on I × n outside the stable region.