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. Author manuscript; available in PMC: 2013 Dec 7.
Published in final edited form as: Cell. 2012 Dec 7;151(6):1283–1295. doi: 10.1016/j.cell.2012.10.041

Figure 1. Mechanotransduction defects in TMHS-deficient mice.

Figure 1

(A) Hair cell diagram showing on the right proteins that form tip links or are located in proximity to tip links. (B) Amplitude of mechanotransduction currents in mutant mouse lines. The values are expressed relative to the values in wild-type. The number of hair cells analyzed is indicated. Values are mean ± SEM. (C) In situ hybridization with TMHS antisense, sense control probes, and a Loxhd1 probe that reveals hair cells. The lowest panel shows vestibular hair cells, the magnified images hair cells at the apical-medial turn of the cochlea. Arrows point to hair cells. (D) SEM analysis of hair bundles from the mid-apical cochlea. On the right, OHCs are shown. The different rows of stereocilia have been colored. Whisker plots on the right show height differences between the first (longest) and second row of stereocilia (yellow); the second and third row (orange); the third row and surface of hair cells or lowest row (green) (number of evaluated hair bundles: control, n=16; Tmhs-/-, n=21; hPDZ, n=21; rumba, n=12; from 2 animals each). Scale bars: (C) black bar: 200 μm; white bar, 50 μm; gray bar, 20 μm; (D) left panel: 5 μm; right panel 2 μm. See also Figure S1.