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| Sex | WT (n=870) | HREM (n=189) |
| Male | 564 (64.8%) | 101 (53.4%) |
| Female | 306 (35.2%) | 88 (46.6%) |
| Site of symptom onset | WT (n=818) | HREM (n=203) |
| Bulbar | 219 (26.8%) | 77 (37.9%) |
| Spinal | 573 (70%) | 110 (54.1%) |
| FTD | 26 (3.2%) | 16 (8%) |
Male to female ratios and frequencies of limb, bulbar and FTD onset in WT and HREM-positive cases.
