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. 2012 Jun 13;21(1):55–61. doi: 10.1038/ejhg.2012.117

Figure 2.

Figure 2

Photomicrographs showing IHC staining of the mismatch repair proteins PMS2 (left side) and MLH1 (right side) in malignancies of the three patients. The inset in panel (d) and (f) show staining for MSH2 as positive control. The muco-epidemoid carcinoma in the parotis of patient 1 (panel (a) and (b)) shows isolated PMS2 expression loss in neoplastic cells and surrounding normal tissue while MLH1 is expressed. A mediastinal mass biopsy of the T-cell lymphoblastic lymphoma of patient 2 (panel (c) and (d)) shows MLH1 and concomitant PMS2 expression loss. Weak, equivocal reactivity in background cells is of uncertain significance and may result from weak expression of the aberrant MLH1-L73R protein. The spinal cord anaplastic astrocytoma of patient 3 (panel (e) and (f)) shows PMS2 and MLH1 loss in neoplastic cells.