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. 2012 Oct 26;287(51):42588–42600. doi: 10.1074/jbc.M112.406413

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Resveratrol decreases levels of BDNF and pCREB. A, levels of BDNF protein in tissue homogenates of hippocampi from vehicle or resveratrol-treated mice were measured using a quantitative ELISA assay. Resveratrol decreased BDNF protein levels in the hippocampus. Values are mean ± S.E. (n = 5 mice/group). *, p < 0.05 versus vehicle (ANOVA with Fisher's PLSD procedure). B, reductions in the levels of pCREB (Ser-133) in the dentate gyrus of vehicle and resveratrol-treated mice were evaluated by immunohistochemistry using pCREB antibody. Scale bar, 100 μm. Quantitative analysis of pCREB-positive cell numbers in the dentate gyrus. **, p < 0.01 versus vehicle (ANOVA with Fisher's PLSD procedure). C, resveratrol decreased BDNF levels in primary cortical neurons. To measure BDNF levels in primary cortical neurons, BDNF ELISA was carried out in primary cortical neuron lysates. Values are means ± S.E. (n = 8).