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. 2012 Oct 25;287(51):42654–42663. doi: 10.1074/jbc.M112.397950

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — Model of transcriptional repression beneath the NE by LBR. A, permissive (top) or nonpermissive (bottom) modifications of histone H4 for binding with LBR. B and C, heterochromatin formation by LBR. B, chromatin compaction. The tudor domain of LBR binds to chromatin-bearing histone H4 with permissive modifications. The RS domain of LBR tethers chromatin through its multimerization. C, transcriptional repressor loading. The NP domain of LBR recruits transcriptional repressors such as HP1, MeCP2, and lamin B.