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Effect of central leptin gene therapy and increased body mass (BM) on distal femur bone volume/tissue volume (a), trabecular number (b), trabecular thickness (c), and trabecular spacing (d) in ob/ob mice administered either rAAV-GFP (control vector) or rAAV-lep icv (Experiment 2). All data are mean ± SE. NS, not significant, P>0.05.
