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. Author manuscript; available in PMC: 2013 Jan 10.
Published in final edited form as: Nat Commun. 2012 Jul 10;3:946. doi: 10.1038/ncomms1947

Figure 1.

Figure 1

Sequence conservation among Rtr1 and RPAP2 homologs. Sequence alignment of full-length K. lactis, S. cerevisiae, and A. gossypii Rtr1 (KlRtr1, ScRtr1, AgRtr1), and human RPAP2 (HsRPAP2, residues 1-240 only, out of 612 residues total) is shown. The four zinc ligand residues are shown in orange. Residues conserved among 11 fungal Rtr1 homologs (excluding the second Rtr1 homolog in S. cerevisiae) or 8 animal RPAP2 homologs are shown in magenta. Residues conserved among fungal Rtr1 and animal RPAP2 homologs are shown in red. Residues not observed in the crystal structure of KlRtr1 are shown in lower-case italic. The secondary structure elements (S. S.) are labeled.