Table 1.
Distribution and statistical analysis of the PGBD1 polymorphisms and their 2, 3, and 4 SNP-based haplotype analyses with APOE genotype distribution
| a PGBD1 polymorphisms and their 2, 3, and 4 SNP-based haplotype analyses | ||||||||||||||
| Genotype frequency, n (%) | p value | HWE | Allele frequency n (%) | χ2 | p value | OR | Haplotype analysis (global p value) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C*/AD** | (95% CI) | 2 SNP-based | 3 SNP-based | 4 SNP-based | ||||||||||
| rs2142731 | A/A | A/G | G/G | A | G | 1.057 | ||||||||
| AD | 128 (60.7) | 74 (35.1) | 9 (4.3) | 0.858 | 0.472/0.831 | 330 (78.2) | 92 (21.8) | 0.095 | 0.758 | (0.788–1.502) | ||||
| C | 91 (58.3) | 59 (37.8) | 6 (3.8) | 241 (77.2) | 71 (22.7) | 0.718 | ||||||||
| rs3800324 | G/G | G/A | A/A | G | A | 1.062 | ||||||||
| AD | 91 (43.1) | 95 (45.0) | 25 (11.8) | 0.930 | 0.857/0.900 | 277 (65.6) | 145 (34.4) | 0.146 | 0.703 | (0.779–1.448) | 0.525 | |||
| C | 70 (44.9) | 69 (44.2) | 17 (10.9) | 209 (67.0) | 103 (33.0) | 0.852 | 0.343 | |||||||
| rs3800327 | G/G | G/C | C/C | G | C | 1.103 | ||||||||
| AD | 62 (29.4) | 112 (53.1) | 37 (17.5) | 0.781 | 0.602/0.330 | 236 (55.9) | 186 (44.1) | 0.425 | 0.515 | (0.821–1.483) | 0.405 | |||
| C | 51 (32.7) | 80 (51.3) | 25 (16.0) | 182 (58.3) | 130 (41.7) | 0.210 | ||||||||
| rs2142730 | C/C | C/T | T/T | C | T | 1.305 | ||||||||
| AD | 102 (48.3) | 95 (45.0) | 14 (6.6) | 0.118 | 0.871/0.254 | 299 (70.9) | 123 (29.1) | 2.781 | 0.095 | (0.954–1.786) | ||||
| C | 67 (42.9) | 69 (44.2) | 20 (12.8) | 203 (65.1) | 109 (34.9) | |||||||||
| b APOE genotype distribution | |||||||||||||
| Genotype frequency, n (%) |
p value | Allele frequency, n (%) | χ2 | OR1 (95% CI) | p value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ∊2/∊2 | ∊2/∊3 | ∊2/∊4 | ∊3/∊3 | ∊3/∊4 | ∊4/∊4 | ∊2 ∊3 | ∊4 | ||||||
| AD | 1 (0.5) | 4 (1.9) | 3 (1.4) | 117 (55.5) | 66 (31.3) | 20 (9.5) | 0.0017 | 9 (2.1) | 304 (72.0) | 109 (25.8) | 17.4 | 2.177 | 0.0001 |
| C | 4 (2.6) | 5 (3.2) | 0 (0) | 106 (67.9) | 39 (25.0) | 2 (1.3) | 13 (4.2) | 256 (82.1) | 43 (13.8) | (1.477–3.215) | |||
C = Controls. p value in bold indicate statistical significance (p < 0.05). 1 ∊4 vs. others.