Table 2.
OC pharmacokinetic parameter estimates in normal weight versus obese women
| Variable | Normal weight (n = 13) |
Obese (n = 15) |
p-value1 |
|---|---|---|---|
| EE | |||
| AUC2 (pg*h/mL) |
1413.7 (1042.5, 1917.1) | 1077.2 (749.9, 1547.6) | 0.04 |
| Cmax (pg/mL) |
129.5 (94.0, 178.4) | 85.7 (57.7, 127.3) | < 0.01 |
| Tmax (h) |
3.0 (2.0, 3.0) | 1.5 (1.0, 2.0) | 0.04 |
| Elimination half-life3 (h) |
28.0 (14.7, 53.3) | 30.4 (20.5, 45.1) | 0.19 |
| Cmin (pg/mL at t24) |
34.2 (23.6, 49.6) | 31.5 (21.4, 46.5) | 0.37 |
| LNG | |||
| AUC2 (ng*h/mL) |
85.8 (61.9, 119.0) | 79.9 (45.0, 142.0) | 0.66 |
| Cmax (ng/mL) |
7.0 (5.2, 9.4) | 5.6 (3.9, 8.1) | 0.19 |
| Tmax (h) |
2.0 (1.5, 2.0) | 1.5 (1.0, 2.0) | 0.18 |
| Elimination half-life3 (h) |
37.6 (18.9, 74.7) | 73.6 (39.5, 137.1) | < 0.01 |
| Cmin (ng/mL at t24) |
2.5 (1.5, 4.0) | 2.6 (1.5, 4.5) | 0.56 |
Tmax shown as median (Q1, Q3); other parameter estimates shown as geometric mean ± SD.
1
Wilcoxon rank-sum test.
2
AUC calculated from t0 to t24.
3
Elimination half-life calculated using values from t12, t16, and t24.