Figure 4. Representative sections of atherosclerotic lesions stained with H&E (A and B) and anti-chymase (C) and anti-CPA (D) antibodies.

Severe atherosclerotic lesions were confirmed by H&E staining (A). The rectangle bounded by black line indicates the areas magnified in (B), (C) and (D). ‘Ad’ and ‘In’ refer to adventitial and intimal sides, respectively. Black arrows indicate the co-localization of chymase and CPA with extensive degranulation of MCs.