Table 4.

Parameter Values for Simulated Test Scores

Parameter	Test Values
Intercept	For non-diseased patients, μ0=0. For diseased patients, μ1=1.53.
Fixed modality effect	Under the null hypothesis, τit=0 for i=1 and 2 and t=0 and 1. Under the alternative hypothesis, τi0=0 for i=1 and 2, and τ11=0 and τ21=0.25.
Random effect due to reader j	Two values of ${\sigma }_r^2$ were tested: 0.011 and 0.056 to represent small and large inter-reader variability.
Random effect due to case k	${\sigma }_C^2$ was set to 0.1.
Random effect due to modality × reader	Two values of ${\sigma }_{\tau R}^2$ were tested: 0.03 and 0.06.
Random effect due to modality × case	${\sigma }_{\tau C}^2$ was set to 0.1.
Random effect due to reader × case	${\sigma }_{RC}^2$ was set to 0.2.
Random effect due to pure error	${\sigma }_{\tau RC}^2$ was set to 0.2.