Table 2.

Inclusion and Exclusion Criteria

INCLUSION CRITERIA
DATABASES	Medline, Google Scholar, EMBASE, Ovid
SOURCH DATE/PUBDATE	1st April 2012/1982-2011
ARTICLE’S LENGUAGE	English, French, Spanish, German, Italian
LEVEL OF EVIDENCE	Oxford centre of EBM, level I, II, III, IV
DIAGNOSIS	Non-unions results of fractures
LESION ASSESSMENT	Imaging: MRI, TC Surgical: Open
TYPE OF SURGERY	stabilization of the fracture, debridement and application of tissue engineered
OUTCOMES ASSESSMENT	Clinical: Clinical examination Imaging: MRI, TC evaluation
MINIMUM FOLLOW-UP TIME	6 months
EXCLUSION CRITERIA	Literature reviews, case reports, studies on animals, cadavers or in vitro, biomechanical reports, tumoral studies, technical notes, letters to editors and instructional course
TYPE OF STUDY	All articles reporting outcomes on tissue engineered strategies, performed singularly or in combination with other surgical procedures, for the management of non-unions.
OUTCOMES MESURES	no information on diagnosis, follow up, imaging of the non-unions, clinical examination, clinical post operative outcomes, statistical analysis of the relative outcomes.