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The AgOr48 complex responds to ε-lactones. (A) Representative whole-cell currents of an AgOr48 + AgOrco cell during application of various ε-lactones (1 µM). Holding potential is −60 mV. (B) Concentration-response curves generated from Ca++-imaging assays on AgOr48 + AgOrco cells (n = 4). Data points represent the mean ± SEM and percent maximal response is normalized to the plate standard, δ-decalactone. EC50 values from the curve fit can be found in Supplementary Table S1.
