Table 2.
Parameter | Pre | Post | p |
---|---|---|---|
Serum sodium (mmol/L)* | 141 ± 3 | 139 ± 3 | .07 |
Serum potassium (mmol/L)* | 4.5 ± 0.4 | 4.6 ± 0.6 | .46 |
Serum creatinine (mg/dL)* | 1.0 ± 0.2 | 1.2 ± 0.3 | .02 |
Blood urea nitrogen (mg/dL)* | 28 ± 13 | 41 ± 24 | .03 |
24-hour creatinine clearance (ml/min/1.73 m2) | 66 ± 35 | 57 ± 30 | .11 |
Serum cystatin C (mg/dL) | 1.34 | 1.41 | .65 |
24-hour urinary sodium (mg/24 hr) | 3353 ± 1593 | 1478 ± 933 | <.001 |
24-hour urinary potassium (mg/24 hr) | 2284 ± 793 | 2925 ± 1024 | .04 |
One subject was withdrawn at safety visit for elevated serum potassium (see text); safety visit values for these parameters are included in ‘Post’ column