Table 3.
Five-year relative survival of breast cancer patients by age and stage
|
stage |
Germany (Saarland) |
US (SEER 9/13 regionsa) |
|||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |
|
1993-96 |
1997-00 |
2001-04 |
2005-08 |
Δ |
p-value |
1993-96 |
1997-00 |
2001-04 |
2005-08 |
Δ |
p-value |
||||||||
| RS | SE | RS | SE | RS | SE | RS | SE | RS | SE | RS | SE | RS | SE | RS | SE | ||||||
| overall |
crude |
73.0 |
1.1 |
77.1 |
1.0 |
80.1 |
0.9 |
84.2 |
0.9 |
11.2 |
<0.001 |
84.1 |
0.2 |
86.3 |
0.2 |
88.2 |
0.1 |
88.6 |
0.1 |
4.5 |
<0.001 |
| |
age std b |
72.2 |
1.3 |
76.3 |
1.2 |
79.0 |
1.1 |
82.5 |
1.0 |
10.3 |
<0.001 |
84.2 |
0.2 |
86.3 |
0.2 |
88.2 |
0.2 |
88.1 |
0.2 |
3.9 |
<0.001 |
| |
stage mix std c |
78.8 |
1.1 |
82.3 |
0.9 |
85.3 |
0.8 |
87.9 |
0.7 |
9.1 |
<0.001 |
84.1 |
0.2 |
85.7 |
0.1 |
87.7 |
0.1 |
88.1 |
0.1 |
4.0 |
<0.001 |
| |
15-49 years |
75.4 |
2.0 |
78.6 |
1.8 |
83.9 |
1.6 |
87.7 |
1.4 |
12.3 |
<0.001 |
82.8 |
0.3 |
85.2 |
0.3 |
87.3 |
0.2 |
89.2 |
0.2 |
6.4 |
<0.001 |
| |
50-69 years |
74.7 |
1.4 |
79.1 |
1.3 |
81.7 |
1.1 |
88.6 |
1.0 |
14.0 |
<0.001 |
85.4 |
0.2 |
87.5 |
0.2 |
89.8 |
0.2 |
90.0 |
0.2 |
4.7 |
<0.001 |
| |
15-69 years |
74.9 |
1.2 |
78.9 |
1.0 |
82.3 |
0.9 |
88.4 |
0.8 |
13.5 |
<0.001 |
84.4 |
0.2 |
86.7 |
0.2 |
88.9 |
0.1 |
89.7 |
0.1 |
5.3 |
<0.001 |
| |
> = 70 years |
69.3 |
2.4 |
73.6 |
2.2 |
75.1 |
2.1 |
74.9 |
2.1 |
5.6 |
0.026 |
83.6 |
0.4 |
85.5 |
0.4 |
86.5 |
0.4 |
85.7 |
0.4 |
2.1 |
0.001 |
| localized |
crude |
90.7 |
1.5 |
93.3 |
1.2 |
96.0 |
1.0 |
97.5 |
0.9 |
6.8 |
0.002 |
95.4 |
0.2 |
96.1 |
0.2 |
97.0 |
0.2 |
97.2 |
0.1 |
1.8 |
<0.001 |
| |
age std b |
91.4 |
2.4 |
94.5 |
1.9 |
97.4 |
1.6 |
98.7 |
1.4 |
7.3 |
<0.001 |
95.7 |
0.2 |
96.3 |
0.2 |
97.3 |
0.2 |
97.3 |
0.2 |
1.6 |
<0.001 |
| |
15-49 years |
86.9 |
2.5 |
92.3 |
1.9 |
93.1 |
1.6 |
95.3 |
1.4 |
8.4 |
0.011 |
93.6 |
0.3 |
94.1 |
0.2 |
95.4 |
0.2 |
96.3 |
0.2 |
2.7 |
<0.001 |
| |
50-69 years |
91.7 |
1.8 |
91.6 |
1.5 |
95.4 |
1.2 |
98.7 |
0.9 |
7.0 |
0.001 |
95.4 |
0.2 |
96.4 |
0.2 |
97.4 |
0.2 |
97.6 |
0.2 |
2.2 |
<0.001 |
| |
15-69 years |
90.1 |
1.5 |
91.8 |
1.2 |
94.7 |
0.9 |
97.8 |
0.7 |
7.7 |
<0.001 |
94.8 |
0.2 |
95.6 |
0.1 |
96.8 |
0.1 |
97.2 |
0.1 |
2.4 |
<0.001 |
| |
> = 70 years |
93.2 |
4.6 |
98.3 |
3.5 |
99.9 |
2.9 |
96.6 |
2.9 |
3.4 |
0.555 |
96.7 |
0.5 |
97.0 |
0.4 |
97.5 |
0.4 |
97.4 |
0.4 |
0.7 |
0.290 |
| |
T1 age std b |
97.3 |
4.0 |
99.3 |
2.9 |
99.5 |
2.4 |
104.1 |
1.8 |
6.8 |
- |
98.8 |
0.3 |
99.5 |
0.2 |
99.9 |
0.2 |
100.4 |
0.2 |
1.7 |
- |
| |
T2-3 age std b |
89.4 |
3.7 |
92.1 |
2.9 |
93.9 |
2.4 |
92.1 |
2.4 |
2.7 |
0.110 |
86.3 |
0.6 |
87.0 |
0.5 |
89.7 |
0.5 |
89.3 |
0.5 |
3.0 |
<0.001 |
| local/regional spread |
crude |
65.2 |
1.8 |
70.9 |
1.7 |
76.4 |
1.5 |
81.1 |
1.5 |
15.9 |
<0.001 |
75.8 |
0.4 |
79.0 |
0.3 |
83.3 |
0.3 |
85.0 |
0.3 |
9.2 |
<0.001 |
| |
age std b |
64.0 |
2.2 |
70.3 |
2.0 |
74.8 |
1.9 |
78.6 |
1.8 |
14.6 |
<0.001 |
75.1 |
0.4 |
77.5 |
0.4 |
81.7 |
0.4 |
82.8 |
0.4 |
7.6 |
<0.001 |
| 15-49 years |
70.7 |
3.4 |
71.4 |
3.1 |
81.1 |
2.7 |
82.6 |
2.6 |
11.9 |
0.004 |
75.5 |
0.6 |
80.2 |
0.5 |
83.5 |
0.4 |
86.8 |
0.4 |
11.3 |
<0.001 |
|
| |
50-69 years |
65.3 |
2.5 |
72.2 |
2.2 |
77.6 |
1.9 |
86.2 |
1.7 |
20.8 |
<0.001 |
78.1 |
0.5 |
80.6 |
0.4 |
86.3 |
0.3 |
87.1 |
0.3 |
9.1 |
<0.001 |
| |
15-69 years |
66.9 |
2.0 |
71.9 |
1.8 |
78.6 |
1.6 |
85.1 |
1.4 |
18.2 |
<0.001 |
76.9 |
0.4 |
80.4 |
0.3 |
85.2 |
0.3 |
87.0 |
0.2 |
10.0 |
<0.001 |
| |
> = 70 years |
61.1 |
4.0 |
68.7 |
3.7 |
70.5 |
3.7 |
70.8 |
3.6 |
9.7 |
0.084 |
72.4 |
0.9 |
74.3 |
0.8 |
76.7 |
0.8 |
77.5 |
0.8 |
5.1 |
<0.001 |
| |
T1/2 age std b |
73.0 |
3.1 |
79.3 |
2.7 |
84.4 |
2.4 |
85.6 |
2.2 |
12.6 |
<0.001 |
81.4 |
0.5 |
83.6 |
0.5 |
87.7 |
0.4 |
88.1 |
0.4 |
6.7 |
<0.001 |
| |
T3/4 age std b |
47.1 |
3.6 |
52.3 |
3.5 |
56.2 |
3.4 |
64.3 |
3.2 |
17.2 |
<0.001 |
64.3 |
1.0 |
68.1 |
0.9 |
71.7 |
0.8 |
68.8 |
0.8 |
4.5 |
0.001 |
| distant metastasis |
crude |
20.2 |
3.0 |
21.9 |
3.0 |
20.1 |
2.6 |
23.0 |
3.0 |
2.8 |
0.111 |
21.2 |
0.7 |
24.1 |
0.7 |
27.2 |
0.7 |
29.2 |
0.7 |
7.9 |
<0.001 |
| |
age std b |
20.3 |
3.2 |
22.1 |
3.0 |
19.0 |
2.6 |
23.7 |
3.0 |
3.3 |
0.106 |
20.2 |
0.7 |
22.5 |
0.7 |
25.2 |
0.7 |
26.7 |
0.7 |
6.5 |
<0.001 |
| |
15-49 years |
11.5 |
5.8 |
17.9 |
8.9 |
26.9 |
7.6 |
29.6 |
9.1 |
18.2 |
0.029 |
26.8 |
1.5 |
31.5 |
1.4 |
34.5 |
1.4 |
38.8 |
1.4 |
11.9 |
<0.001 |
| |
50-69 years |
25.3 |
4.4 |
24.7 |
4.4 |
23.6 |
4.0 |
29.1 |
4.6 |
3.8 |
0.237 |
21.3 |
1.0 |
24.4 |
1.0 |
29.0 |
1.0 |
30.5 |
1.0 |
9.2 |
<0.001 |
| |
15-69 years |
22.0 |
3.7 |
23.9 |
3.9 |
24.5 |
3.5 |
28.5 |
4.1 |
6.5 |
0.058 |
23.2 |
0.9 |
26.9 |
0.8 |
30.9 |
0.8 |
33.2 |
0.8 |
10.0 |
<0.001 |
| |
> = 70 years |
17.2 |
5.9 |
19.3 |
4.7 |
13.3 |
3.7 |
15.3 |
4.2 |
−1.9 |
0.712 |
17.4 |
1.1 |
18.2 |
1.1 |
19.0 |
1.1 |
19.4 |
1.1 |
2.1 |
0.045 |
| unknown stage |
crude |
78.4 |
2.5 |
81.3 |
2.8 |
77.0 |
3.5 |
81.4 |
2.8 |
3.0 |
0.381 |
55.2 |
1.2 |
57.7 |
1.2 |
55.0 |
1.4 |
43.5 |
1.5 |
−11.7 |
<0.001 |
| age std b | 78.7 | 2.5 | 82.1 | 2.7 | 77.6 | 3.2 | 82.7 | 2.5 | 4.0 | 0.084 | 55.6 | 1.3 | 59.0 | 1.2 | 56.1 | 1.5 | 45.2 | 1.6 | −10.4 | <0.001 | |
Five-year relative survival of female patients with invasive breast cancer (ICD-10 code: C50) from Germany (Saarland) and the US (SEER 9/13 regions) by age and stage for successive calendar periods.
RS: relative survival (period estimate) in %; SE: standard error; std: standardized; Δ : difference of RS between 2005–08 and 1993–96 in % units; a the coverage of SEER program was extended from 9 to 13 registries in 1992; b using weights from the International Cancer Survival Standards [33]; c weights derived from the SEER patients diagnosed 1988–2008.