Table 14.
Effect of DAS-77 on antioxidant enzymes in rat kidney in the reversibility study
|
Treatment |
Dose (mg/kg) |
Reversibility study |
|||||
|---|---|---|---|---|---|---|---|
| GSH (nm/mg) | SOD (u/mg) | CAT (u/mg) | Peroxidase (u/mg) | MDA (nm/mg) | Protein (mg) | ||
|
Distilled water |
(10 ml/kg) |
2.03 ± 0.37 |
3.30 ± 0.45 |
15.24 ± 2.08 |
1.04 ± 0.14 |
0.13 ± 0.01 |
32.56 ± 1.70 |
|
DAS-77 |
80 |
2.22 ± 0.46 |
3.48 ± 0.59 |
16.07 ± 2.70 |
1.09 ± 0.18 |
0.15 ± 0.02 |
30.88 ± 4.35 |
|
DAS-77 |
400 |
1.09 ± 0.14 |
2.04 ± 0.18 |
9.43 ± 0.85 |
0.64 ± 0.06 |
0.15 ± 0.02 |
35.49 ± 4.60 |
| DAS-77 | 2000 | 2.31 ± 0.42 | 3.05 ± 0.49 | 14.07 ± 2.24 | 0.96 ± 0.15 | 0.14 ± 0.02 | 34.32 ± 5.29 |
Values are mean ± S.E.M. (n = 5, main study). p > 0.05 vs. distilled water (One-way ANOVA followed by Dunnett’s posttest).