Table 8.
Effect of DAS-77 on serum biochemical parameters in rats in the reversibility study
|
Treatment |
Dose(mg/kg) |
Reversibility study |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Creatinine (μmol/L) | Urea (mmol/L) | Albumin (g/L) | Protein (g/L) | TC (mmol/L) | HDL (mmol/L) | LDL (mmol/L) | TG (mmol/L) | Glucose (mmol/L) | Uric acid (μmol/L) | ALP (u/L) | AST (u/L) | ALT (u/L) | TB (μmol/L) | DB (μmol/L) | ||
|
Distilled water |
(10 ml/kg) |
58.75 ± 2.95 |
7.68 ± 0.38 |
39.5 ± 1.68 |
83.13 ± 3.14 |
2.4 ± 0.25 |
1.59 ± 0.15 |
0.50 ± 0.18 |
0.65 ± 0.10 |
1.93 ± 0.36 |
93.74 ± 8.50 |
28.23 ± 5.48 |
65.88 ± 7.87 |
31.75 ± 3.08 |
5.75 ± 0.31 |
1.50 ± 0.27 |
|
DAS-77 |
80 |
60.11 ± 2.67 |
7.72 ± 0.36 |
40.89 ± 1.35 |
84.11 ± 3.25 |
2.18 ± 0.15 |
1.61 ± 0.15 |
0.24 ± 0.04 |
0.70 ± 0.08 |
2.36 ± 0.34 |
85.33 ± 5.54 |
20.11 ± 2.57 |
58.56 ± 5.26 |
26.67 ± 1.62 |
5.22 ± 0.15 |
1.44 ± 0.18 |
|
DAS-77 |
400 |
54.50 ± 1.05 |
7.41 ± 0.52 |
39.00 ± 1.60 |
85.38 ± 3.69 |
2.25 ± 0.33 |
1.61 ± 0.32 |
0.70 ± 0.16 |
0.68 ± 0.13 |
1.84 ± 0.28 |
97.75 ± 10.75 |
25.69 ± 3.09 |
51.50 ± 4.05 |
33.63 ± 2.06 |
5.38 ± 0.26 |
1.50 ± 0.38 |
| DAS-77 | 2000 | 55.50 ± 2.05 | 7.12 ± 0.31 | 38.50 ± 1.34 | 84.67 ± 6.04 | 1.90 ± 0.24 | 1.10 ± 0.18 | 0.47 ± 0.09 | 0.70 ± 0.10 | 2.03 ± 0.48 | 111.20 ± 13.20 | 29.50 ± 3.47 | 74.50 ± 11.22 | 35.33 ± 4.55 | 5.17 ± 0.17 | 1.00 ± .00 |
Values are mean ± S.E.M. (n = 8). p > 0.05 vs. distilled water (One-way ANOVA followed by Dunnett’s posttest).