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. 2012 Dec 14;7(12):e51825. doi: 10.1371/journal.pone.0051825

Figure 3. TRPM8 channel blockers reduce proliferation in prostate cancer cells.

Figure 3

Growth of the indicated cell lines in the presence of TRPM8 inhibitors. MTT hydrolysis, expressed as fold increase, has been normalized to levels at time 0. Clotrimazole (solid squares), BCTC (solid circles), thio-BCTC (open squares) and DD01050 (triangles) over 5 days of experiment. Data points represent average of 4 experiments ± SEM. *: p<0.05; **: p<0.01; ***: p<0.005. The blockers were used in a final concentration of 10 µM.