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. 2012 Dec 14;7(12):e51957. doi: 10.1371/journal.pone.0051957

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© 2012 Wei et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) The average of spot forming units of PBMCs from 6 adult donors stimulated with 37 predicted EV71 CD4+ T cell epitopes and a scrambled peptide SP4. (B) These photos of ELISpot wells are examples of the responses to A3, A8, SP4 and PHA. (C) On average, the spot forming units of A3 and A8 were significantly higher than previously identified CD4+ T cell epitopes, SP1, SP2 and SP3.