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(A) The A3 and A8 epitopes are exactly conserved across EV71 isolates, other HFMD-related viruses, and polioviruses. A14 was not as well conserved. Of the EV71 strains shown, all except for the EV71 prototype BrCr strain were isolated in the recent HFMD outbreaks. (B) A3, but not A8, was conserved among the other enteroviruses.
