Table 1. Baseline characteristics of study participants.
Nephroblastoma | Neuroblastoma | Controls | |||
N | 67 | 36 | 61 | ||
Male/female | 39/28 | 15/21 | 33/28 | ||
Age at follow-up (yrs) | 30.2 (18.8–50.8) | 29.6 (20.4–46.2) | 31.8 (18.0–61.8) | ||
Age at diagnosis (yrs) | 3.3 (0.0–12.7) | 0.8 (0.0–11.7) | n.a. | ||
Follow-up time * (yrs) | 26.2 (6.4–48.9) | 27.8 (15.0–44.4) | n.a. | ||
BMI (SDS) ** | −0.52 (−1.21–0.13) | −0.58 (−1.99–0.16) | 0.08 (−0.51–0.68) | ||
BMI at diagnosis (SDS) ** | 0.08 (−0.63–0.80) | 0.31 (−0.61–0.74) | n.a. | ||
Physical activity score ** | 8280 (6660–12000) | 7130 (5843–9005) | 8330 (6570–11370) | ||
Non smoker | 66% | 50% | 53% | ||
Former smoker | 12% | 19% | 16% | ||
Smoker | 22% | 31% | 31% | ||
Low educational level | 21% | 22% | 16% | ||
Medium educational level | 36% | 33% | 48% | ||
High educational level | 43% | 45% | 36% | ||
(Partial) adrenalectomy (N) | 33/67 | 13/36 | n.a. | ||
(Partial) nephrectomy (N) | 67/67 | 7/36 | n.a. | ||
Radiotherapy abdomen (N) | 35/67 | 7/36 | n.a. | ||
Radiotherapy thorax (N) | 0/67 | 2/36 | n.a. | ||
Radiotherapy neck (N) | 0/67 | 1/36 | n.a. | ||
Radiotherapy spine (N) | 0/67 | 1/36 | n.a. | ||
Cumulative dose radiotherapy (gy) | 20 (15–40) | 20 (10–30) | n.a. | ||
Chemotherapy (N) | 59/67 | 31/36 | n.a. | ||
N | TCD | N | TCD | ||
Vincristin (mg/m2) | 51 | 22.0 (6.0–93.0) | 16 | 22.8 (5.0–65.0) | n.a. |
Actinomycin D (mg/m2) | 48 | 10.9 (0.1–24.8) | 0 | n.a. | n.a. |
Anthracyclines (mg/m2) | 18 | 250 (100–450) | 12 | 210 (100–315) | n.a. |
Cyclophosphamide (mg/m2) | 2 | 3825 (250–7400) | 29 | 7350 (3150–45990) | n.a. |
Cisplatin (mg/m2) | 0 | 0 | 6 | 450 (270–630) | n.a. |
Teniposide (mg/m2) | 0 | 0 | 6 | 500 (300–700) | n.a. |
Dacarbazine (mg/m2) | 2 | 14.7 (13.5–15.8) | 0 | 0 | n.a. |
Iphosphamide (mg/m2) | 2 | 33000 (30000–36000) | 0 | 0 | n.a. |
Data expressed as median (range) unless specified otherwise.
Time after cessation of treatment.
Data expressed as median (interquartile range).
n.a. = not applicable, Gy = gray, TCD = total cumulative dose.