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. 2012 Dec 14;7(12):e52237. doi: 10.1371/journal.pone.0052237

Table 1. Baseline characteristics of study participants.

Nephroblastoma Neuroblastoma Controls
N 67 36 61
Male/female 39/28 15/21 33/28
Age at follow-up (yrs) 30.2 (18.8–50.8) 29.6 (20.4–46.2) 31.8 (18.0–61.8)
Age at diagnosis (yrs) 3.3 (0.0–12.7) 0.8 (0.0–11.7) n.a.
Follow-up time * (yrs) 26.2 (6.4–48.9) 27.8 (15.0–44.4) n.a.
BMI (SDS) ** −0.52 (−1.21–0.13) −0.58 (−1.99–0.16) 0.08 (−0.51–0.68)
BMI at diagnosis (SDS) ** 0.08 (−0.63–0.80) 0.31 (−0.61–0.74) n.a.
Physical activity score ** 8280 (6660–12000) 7130 (5843–9005) 8330 (6570–11370)
Non smoker 66% 50% 53%
Former smoker 12% 19% 16%
Smoker 22% 31% 31%
Low educational level 21% 22% 16%
Medium educational level 36% 33% 48%
High educational level 43% 45% 36%
(Partial) adrenalectomy (N) 33/67 13/36 n.a.
(Partial) nephrectomy (N) 67/67 7/36 n.a.
Radiotherapy abdomen (N) 35/67 7/36 n.a.
Radiotherapy thorax (N) 0/67 2/36 n.a.
Radiotherapy neck (N) 0/67 1/36 n.a.
Radiotherapy spine (N) 0/67 1/36 n.a.
Cumulative dose radiotherapy (gy) 20 (15–40) 20 (10–30) n.a.
Chemotherapy (N) 59/67 31/36 n.a.
N TCD N TCD
Vincristin (mg/m2) 51 22.0 (6.0–93.0) 16 22.8 (5.0–65.0) n.a.
Actinomycin D (mg/m2) 48 10.9 (0.1–24.8) 0 n.a. n.a.
Anthracyclines (mg/m2) 18 250 (100–450) 12 210 (100–315) n.a.
Cyclophosphamide (mg/m2) 2 3825 (250–7400) 29 7350 (3150–45990) n.a.
Cisplatin (mg/m2) 0 0 6 450 (270–630) n.a.
Teniposide (mg/m2) 0 0 6 500 (300–700) n.a.
Dacarbazine (mg/m2) 2 14.7 (13.5–15.8) 0 0 n.a.
Iphosphamide (mg/m2) 2 33000 (30000–36000) 0 0 n.a.

Data expressed as median (range) unless specified otherwise.

*

Time after cessation of treatment.

**

Data expressed as median (interquartile range).

n.a. = not applicable, Gy = gray, TCD =  total cumulative dose.