Table 1. Activation patterns corresponding to the effects of visual WM load.
Brainregion | Hemisphere | Clustersize | T/F | p | x | y | z | |||
A) Main effect ( F -Test) | ||||||||||
Inferior frontal gyrus | L | 2772 | 32.30 | <.001 | −35 | 21 | −6 | |||
R | 1132 | 29.21 | <.001 | 30 | 23 | 0 | ||||
Orbitofrontal gyrus | R | 408 | 25.39 | <.001 | 36 | 54 | −6 | |||
DLPFC | L | 2977 | 8.47 | <.001 | −48 | 26 | 29 | |||
L | 46 | 2.34 | .001 | −39 | 35 | −18 | ||||
L | 27 | 17.09 | .008 | −26 | 17 | −21 | ||||
R | 20 | 18.15 | .004 | 45 | 21 | 12 | ||||
Middle frontal gyrus | L | 143 | 16.58 | .012 | −44 | 47 | 9 | |||
Superior frontal gyrus | L | 29 | 16.91 | .009 | −30 | 57 | 0 | |||
SMA | L | 14751 | 8.44 | <.001 | −5 | 5 | 50 | |||
vmPFC | L | 5385 | 35.47 | <.001 | −6 | 54 | −17 | |||
R | 45 | 21.14 | .001 | 9 | 50 | 26 | ||||
Middle cingulate gyrus | L | 1352 | 25.26 | <.001 | −8 | −45 | 36 | |||
L | 56 | 17.20 | .008 | −5 | −27 | 45 | ||||
Precuneus | R | 108 | 18.57 | .003 | 8 | −59 | 26 | |||
Inferior parietal gyrus | L | 16781 | 68.32 | <.001 | −42 | −41 | 45 | |||
Angular gyrus | L | 118 | 17.06 | .008 | −47 | −63 | 26 | |||
Insula | L | 25 | 2.30 | .001 | −47 | 0 | 14 | |||
R | 166 | 25.00 | <.001 | 39 | −15 | 17 | ||||
R | 56 | 18.80 | .003 | 48 | −29 | 20 | ||||
Inferior temporal gyrus | L | 152 | 21.42 | .001 | −54 | −63 | −15 | |||
Fusiform gyrus | L | 25 | 16.95 | .009 | −32 | −36 | −18 | |||
R | 268 | 23.36 | <.001 | 57 | −56 | −17 | ||||
R | 50 | 19.70 | .001 | 42 | −62 | −15 | ||||
Thalamus | R | 617 | 22.46 | <.001 | 12 | −6 | −2 | |||
Putamen | R | 411 | 2.42 | .001 | 21 | 11 | 2 | |||
Lobule VIIa crus I | L | 2077 | 45.25 | <.001 | −32 | −65 | −32 | |||
R | 133 | 2.98 | .001 | 36 | −78 | −39 | ||||
Lobule VI | R | 5229 | 44.42 | <.001 | 35 | −51 | −32 | |||
Lobule VIIIa | R | 116 | 25.36 | <.001 | 39 | −44 | −54 | |||
Lobule VIIa crus II | R | 172 | 19.55 | .002 | 38 | −63 | −51 | |||
Substantia nigra | L | 69 | 18.87 | .003 | −8 | −20 | −12 | |||
B) Parametric effect ( T -Test conjunction) | ||||||||||
Precentral gyrus | R | 236 | 4.35 | – | 30 | −3 | 47 | |||
SMA | R | 449 | 4.85 | – | 5 | 9 | 51 |
A) The F-contrast (F>14.46) resulted from a group-level GLM, testing for general differences between all visual WM conditions, p<.05, FWE-corrected, k>20). B) The T-contrast conjunction (T>3.24) combined the effects of 2-back>1-back ∩ 1-back>0-back ∩ 0-back>fixation, p<.05, MC-corrected, k>125). P-values are only reported if surviving voxel-level FWE correction. DLPFC = dorsolateral prefrontal cortex, SMA = supplementary motor area, vmPFC = ventromedial PFC.