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. 2012 Dec 14;7(12):e52181. doi: 10.1371/journal.pone.0052181

Figure 2. Ucn 3 expression trails the appearance of insulin in ontogeny.

Figure 2

Ucn 3 expression, undetectable by immunohistochemistry at E12.5 (A, B) and E15.5 (C, D), first appears in a subset of beta cells around E17.5 of embryonic development (E, F). The fraction of Ucn 3+ beta cells increases perinatally (G, H) and by p7, the majority of beta cells (I, J), including those appearing as singlets in the acinar tissue (K) are clearly Ucn 3+. From p14 onwards, Ucn 3 expression is evident in all beta cells (L–O).