Table 1. Neurological statea.
Experements | Group | Score |
The SkQR1 study | Baseline | 14 (14–14) |
Sham+ VEHICLE | 13.5 (13.25–14) | |
MCAO+ VEHICLE | 1 (1–2) | |
MCAO+ SkQR1 0.5 mol/kg | 5 (3–7)* | |
MCAO+ SkQR1 1 µmol/kg | 5.5 (4.5–7.5)* | |
MCAO+ SkQR1 2 µmol/kg | 6.5 (3.75–9.25)* | |
Renal preconditioning | MCAO | 3 (2–3) |
MCAO+ RRPC | 11 (10.5–11)* | |
Bilateral nephrectomy | MCAO | 3 (3–4.5) |
MCAO+ BNe | 5 (3–6) | |
MCAO+BNe+SkQR1 1 µmol/kg | 3,5 (2.75–4.25) | |
Gentamicin-induced | MCAO+GM | 4 (3–9) |
renal failure | MCAO+ GM+SkQR1 1 µmol/kg | 3 (2.75–4) |
MCAO+ GM+RRPC | 4 (2.5–5.5) |
The neurological state scores are recorded in a blind fashion and expressed as median and interquartile ranges, the 25th to 75th percentile are shown in the parentheses. Baseline represents neurological state of intacte rats. *Denotes significant from the score at 24 h after the MCAO compared to MCAO+ VEHICLE or MCAO groups (p<0.05) (Kruskal-Wallis test with the Mann–Whitney u-test with Bonferroni correction post hoc or Mann–Whitney test when comparing between two groups).