. 2012 Dec 14;7(12):e51680. doi: 10.1371/journal.pone.0051680

Table 2. Association of the whole pathway, sub-pathways, and genes of innate immunity and inflammation with advanced prostate cancer risk.

SNP set	SNP count	P-value
		Overall	African American	Caucasian
Inflammation and innate immunity	320	0.02	0.29	0.01
• Cytokine signaling (26 genes)	179	0.44	0.33	0.57
IL10	8	0.34	0.42	0.47
IL12RB2	11	0.75	0.89	0.61
IL6R	1	–^a	–^a	–^a
IL18R1	16	0.11	0.09	0.31
IL1B	4	0.53	0.58	0.59
IL1RN	7	0.42	0.50	0.51
IL12A	4	0.12	0.66	0.13
TGFBR2	33	0.75	0.22	0.78
IL2	5	0.81	0.41	0.63
IL8	4	0.18	1	0.17
IL12B	6	0.45	0.59	0.46
IL13	4	0.84	0.11	0.95
IL4	4	0.41	0.23	0.60
IL5	1	–^a	–^a	–^a
IFNGR1	5	0.006	0.16	0.009
IL17	8	0.41	0.56	0.21
TNF/LTA	11	0.72	0.44	0.92
TGFBR1	6	0.49	0.40	0.52
IL18	8	0.048	0.07	0.08
IFNG	6	0.19	0.20	0.40
IL23A	1	–^a	–^a	–^a
IL12RB1	5	0.57	0.45	0.41
MIC1	6	0.94	0.10	0.51
TGFB1	4	0.22	0.08	0.68
IFNGR2	9	0.72	0.86	0.78
MIF	2	0.36	1	0.23
• Eicosanoid signaling (1 gene: COX2)	9	0.04	0.07	0.09
• Extracellular pattern recognition (8 genes)	56	0.02	0.12	0.01
TLR5	7	0.49	0.69	0.48
TLR1	7	0.002	0.09	0.004
TLR10	7	0.18	0.35	0.07
TLR2	8	0.63	0.28	0.37
TLR3	1	–^a	–^a	–^a
TLR6	5	0.04	0.04	0.04
MSR1	16	0.37	0.09	0.36
TLR4	5	0.11	0.05	0.19
• Intracellular antiviral molecules (4 genes)	40	0.02	0.71	0.01
RNASEL	7	0.31	0.24	0.43
EIF2AK2	11	0.79	0.41	0.44
OAS1	5	0.015	0.92	0.01
OAS2	17	0.019	0.79	0.01
• NFKB^b signaling (5 genes)	27	0.32	0.04	0.48
NFKB1	10	0.70	0.49	0.58
IKBKB	7	0.18	0.46	0.13
CHUK	6	0.14	0.07	0.28
RELA	2	0.16	0.04	0.51
NFKBIA	2	0.67	0.24	0.72
• Selenoproteins (2 genes)	9	0.67	0.93	0.44
SEP15	5	0.37	0.74	0.21
SELS	4	0.95	0.86	0.94

Genes with one SNP;

NFKB: nuclear kappa-light chain-enhancer or activated B cell.