Results for the 3-dimensional γ-index for the PBS test case in Fig. 4a. The comparison uses δd0 = 3 mm, δD0 = 3%, and region of interest denned by 20% of the maximum dose. The depths d1, d2, and d3 are 54 mm, 108 mm, and 162 mm of polystyrene, respectively. At each depth, 1024 measured points in a plane are compared to 562 × 103 voxels from treatment planning. Method A is used as the “gold standard” for determining the accuracy of the other methods. The accuracy of Method B shows that linear interpolation introduces ~ 1% error. Method E is the fastest method with ~ 1% accuracy. Method I is slower than than Method E by a factor of 10, but it can be used to check the magnitude of 2nd-order terms. Method G is only slightly slower than the 2nd-order methods and has accuracy better than 0.2%.