Table IV.

Non-hematologic toxicity for all dose levels¹.

	Grade 1	Grade 2	Grade 3	Grade 4
Vomiting	9 (30%)	5 (16.7%)	6 (20%)	0
Nausea	11 (36.7%)	6 (20%)	2 (6.7%)	0
Neuropathy; sensory	12 (40%)	3 (10%)	1 (3.3%)	0
Hypophosphatemia	10 (33.3%)	3 (10%)	2 (6.7%)	0
AST, elevated	11 (36.7%)	3 (10%)	0	0
Hypokalemia	11 (36.7%)	0	1 (3.3%)	1 (3.3%)
Fatigue	8 (26.7 %)	4 (13.3%)	0	0
ALT, elevated	11 (36.7%)	0	0	0
Hypoalbuminemia	8 (26.7%)	3 (10%)	0	0
Hypocalcemia	9 (30%)	2 (6.7%)	0	0
Diarrhea	9 (30%)	2 (6.7%)	0	0
Hyperglycemia	7 (23.3%)	3 (10%)	1 (3.3%)	0
Hyponatremia	9 (30%)	0	1 (3.3%)	1 (3.3%)
PTT, elevated	8 (26.7%)	0	0	0
Pain, Headache	6 (20%)	2 (6.7%)	0	0
Alkaline Phosphatase, elevated	6 (20%)	0	0	0
Bicarbonate, low	4 (13.3%)	2 (6.7%)	0	0
Fever without neutropenia	4 (13.3%)	1 (3.3%)	1 (3.3%)	0
Pain, Abdomen	4 (13.3%)	1 (3.3%)	1 (3.3%)	0
Hypotension	3 (10%)	0	1 (3.3%)	0
Dyspnea	1 (3.3%)	1 (3.3%)	1 (3.3%)	0
Hemorrhage, nose	2 (6.7%)	0	1 (3.3%)	0
Dehydration	0	0	1 (3.3%)	0
Febrile Neutropenia	0	0	1 (3.3%)	0
SIADH	0	0	0	1 (3.3%)

¹Grade 1 or 2 toxicities occurring in ≥ 20% of patients. All grade 3 or 4 toxicities.