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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Hepatology. 2013 Jan;57(1):339–350. doi: 10.1002/hep.26053

Figure 2. Validation of HSC depletion in vivo in TG mice treated with CCl4+AA+GCV.

Figure 2

(A) Reduction of desmin (green) and GFAP (red) positive cells, and merged images (yellow) by 65% (p<0.01) in TG mice treated with CCl4+AA+GCV, compared to WT mice as assessed by dual-immunofluorescence. (B) Relative GFAP mRNA expression (by qPCR) demonstrates a significant reduction in TG mice undergoing HSC depletion. Data are mean values from three independent experiments normalized to saline-treated mice. GCV treatment (without CCl4+AA) did not differ from saline treated group. Original magnification ×100. *p<0.05.