Table 1.

Linear Regression of DRD2/ANKK1 SNPs on Genetic Factor Scores

DRD2 SNP Information						Genetic Factor Scores
Chr	Gene	SNP	Base Pair Location	Alleles Major; Minor	MAF	Alcohol Consumption and Problems		Alcohol Problems (MAST and RAPI)
						Beta	p-value	Beta	p-value
11	ANKK1	rs2734849	112775370	A;G	0.282	0.094	0.047	0.127	0.006
11	ANKK1	rs2734848	112775584	T;C	0.220	−0.040	0.401	−0.040	0.391
11	ANKK1	rs1800497	112776038	G;A	0.330	−0.003	0.945	−0.035	0.451
11	DRD2	rs11214599	112776570	C;T	0.330	−0.007	0.886	−0.043	0.353
11	DRD2	rs11214601	112777972	C;T	0.330	−0.004	0.936	−0.041	0.373
11	DRD2	rs2587550	112778135	A;G	0.120	−0.096	0.042	−0.103	0.026
11	DRD2	rs12422191	112779220	G;A	0.900	0.001	0.981	0.034	0.460
11	DRD2	rs10891549	112783657	T;C	0.235	0.098	0.004	0.130	0.005
11	DRD2	rs2234689	112783693	C;G	0.220	0.040	0.401	0.040	0.391
11	DRD2	rs1554929	112783974	C;T	0.235	0.098	0.039	0.130	0.005
11	DRD2	rs6279	112786283	C;G	0.118	−0.096	0.042	−0.103	0.003
11	DRD2	rs1124491	112787300	G;A	0.330	0.005	0.914	−0.042	0.367
11	DRD2	rs1079595	112787879	A;C	0.330	−0.004	0.936	−0.041	0.373
11	DRD2	rs6275	112788687	G;A	0.117	−0.099	0.038	−0.102	0.003
11	DRD2	rs2440390	112792088	C;T	0.080	−0.051	0.285	−0.014	0.757
11	DRD2	rs1079727	112794392	T;C	0.030	0.006	0.906	−0.035	0.444
11	DRD2	rs2734833	112798130	A;G	0.241	−0.098	0.038	−0.108	0.019
11	DRD2	rs1076562	112801218	G;A	0.095	−0.107	0.024	−0.087	0.060
11	DRD2	rs7131440	112805120	T;C	0.254	−0.104	0.028	−0.105	0.023
11	DRD2	rs17115583	112814112	G;A	0.043	−0.091	0.056	−0.081	0.081
11	DRD2	rs11214606	112815079	C;T	0.010	−0.007	0.875	−0.012	0.794
11	DRD2	rs4648318	112818599	T;C	0.103	−0.105	0.026	−0.074	0.111
11	DRD2	rs17529477	112822277	G;A	0.033	0.052	0.267	0.042	0.359
11	DRD2	rs17601612	112822955	G;C	0.063	0.025	0.595	0.035	0.446
11	DRD2	rs4245147	112823217	T;C	0.099	0.033	0.494	0.068	0.143
11	DRD2	rs4245148	112825629	C;T	0.060	0.033	0.491	0.089	0.053
11	DRD2	rs7131056	112834984	C;A	0.226	0.078	0.100	0.040	0.391
11	DRD2	rs4245149	112843567	G;A	0.052	−0.070	0.141	−0.079	0.087
11	DRD2	rs1799978	112851561	A;G	0.050	−0.044	0.255	0.019	0.684
11	DRD2	rs12364283	112852165	A:G	0.011	−0.021	0.655	0.000	0.997
11	DRD2	rs10891556	112857971	G;T	0.052	−0.073	0.126	−0.072	0.120

Note: SNPs that passed Nyholt threshold for significant association (p<0.005) are bolded. The reference build used in this table was HapMap Data Release 28 Phase II+III, August10, on NCBI B36 assesmbly dbSNP b126. The major allele frequencies (MAF) presented in this table were calculated using only one individual per family.