The p-BNC diagnostic applications for cardiovascular disease include (A) Risk for primary cardiac event chip: Apolipoprotein A1 (ApoA1), Apolipoprotein B (ApoB), C-reactive protein (CRP), Interleukin-1beta (IL-1b), Monocyte chemoattractant protein-1 (MCP-1), Tumor necrosis factor-alpha (TNF-a), Soluble CD40 ligand (sCD40L), Human serum albumin (hsa), Interleukin-6 (IL-6) and Myeloperoxidase (MPO); (B) Expanded AMI diagnosis chip: Cardiac troponin I (cTnI), Myoglobin (CRP), IL-1β, MPO and MYO; (C) Risk for secondary cardiac events chip: ApoA1, ApoB and D-dimer; and (D) Congestive heart failure chip: Brain natriuretic peptide (BNP)