Table 1.
Biochemicals involved in lipid metabolic pathways
| PATHWAY | SUB PATHWAY | BIOCHEMICAL NAME | KEGG | CPT1c KOCPT1c WT | Welch's Two-Samplet-Test | CAS | PUBCHEM |
|---|---|---|---|---|---|---|---|
| Lipid |
Essential fatty acid |
linoleate (18:2n6) |
C01595 |
0.93 |
0.4643 |
60-33-3; |
5280450 |
| linolenate [alpha or gamma; (18:3n3 or 6)] |
C06427 |
1.04 |
0.4808 |
|
|
||
| dihomo-linolenate (20:3n3 or n6) |
C03242 |
0.81 |
0.0608 |
|
5312529 |
||
| eicosapentaenoate (EPA; 20:5n3) |
C06428 |
0.72 |
0.0236 |
10-2005-9;10417-94-4; |
446284 |
||
| docosapentaenoate (n3 DPA; 22:5n3) |
C16513 |
0.80 |
0.0662 |
2234-74-4; |
|
||
| docosapentaenoate (n6 DPA; 22:5n6) |
C06429 |
0.77 |
0.3030 |
25182-74-5; |
6441454 |
||
| docosahexaenoate (DHA; 22:6n3) |
C06429 |
0.89 |
0.2879 |
6217-54-5; |
445580 |
||
|
Medium chain fatty acid |
caproate (6:0) |
C01585 |
0.98 |
0.5408 |
142-62-1; |
8892 |
|
| caprylate (8:0) |
C06423 |
0.99 |
0.9309 |
124-07-2; |
379 |
||
| pelargonate (9:0) |
C01601 |
0.89 |
0.1531 |
112-05-0; |
5461016 |
||
| laurate (12:0) |
C02679 |
1.01 |
0.9051 |
143-07-7; |
3893 |
||
|
Long chain fatty acid |
myristate (14:0) |
C06424 |
0.99 |
0.8942 |
544-63-8; |
11005 |
|
| myristoleate (14:1n5) |
C08322 |
1.26 |
0.1786 |
544-64-9; |
5281119 |
||
| palmitate (16:0) |
C00249 |
0.85 |
0.0781 |
57-10-3; |
985 |
||
| palmitoleate (16:1n7) |
C08362 |
0.93 |
0.3794 |
373-49-9; |
445638 |
||
| margarate (17:0) |
|
0.86 |
0.2288 |
506-12-7; |
10465 |
||
| 10-heptadecenoate (17:1n7) |
|
0.81 |
0.1051 |
29743-97-3; |
5312435 |
||
| stearate (18:0) |
C01530 |
0.94 |
0.4536 |
57-11-4; |
5281 |
||
| oleate (18:1n9) |
C00712 |
0.88 |
0.2434 |
112-80-1; |
445639 |
||
| 10-nonadecenoate (19:1n9) |
|
0.72 |
0.0470 |
73033-09-7; |
5312513 |
||
| eicosenoate (20:1n9 or 11) |
|
0.78 |
0.1453 |
|
|
||
| dihomo-linoleate (20:2n6) |
C16525 |
0.75 |
0.0804 |
2091-39-6; |
6439848 |
||
| arachidonate (20:4n6) |
C00219 |
0.94 |
0.4832 |
506-32-1; |
444899 |
||
| docosadienoate (22:2n6) |
C16533 |
0.84 |
0.3185 |
7370-49-2; |
5282807 |
||
| adrenate (22:4n6) |
C16527 |
0.81 |
0.1467 |
2091-25-0; |
5282844 |
||
|
Fatty acid, ester |
n-Butyl Oleate |
|
0.96 |
0.7046 |
142-77-8; |
5354342 |
|
|
Fatty acid, dicarboxylate |
2-hydroxyglutarate |
C02630 |
1.00 |
0.8616 |
40951-21-1; |
43 |
|
|
Fatty acid, amide |
oleamide |
|
1.22 |
0.7962 |
301-02-0; |
5283387 |
|
| stearamide |
C13846 |
1.19 |
0.6546 |
124-26-5; |
31292 |
||
|
Eicosanoid |
prostaglandin D2 |
C00696 |
1.20 |
0.1092 |
41598-07-6; |
448457 |
|
| prostaglandin E2 |
C00584 |
0.93 |
0.3928 |
363-24-6; |
5280360 |
||
| 5-HETE |
|
0.99 |
0.8472 |
73307-52-5; |
9862886 |
||
| 15-HETE |
C04742 |
0.83 |
0.9669 |
54845-95-3; |
5280724 |
||
|
Endocannabinoid |
palmitoyl ethanolamide |
|
0.64 |
0.0331 |
|
4671 |
|
|
Fatty acid & BCAA metabolism |
propionylcarnitine |
C03017 |
1.08 |
0.4494 |
17298-37-2; |
107738 |
|
|
Carnitine metabolism |
carnitine |
C00487 |
0.88 |
0.0084 |
461-05-2; |
288 |
|
| 3-dehydrocarnitine* |
C02636 |
1.22 |
0.0103 |
10457-99-5; |
6991982 |
||
| acetylcarnitine |
C02571 |
0.89 |
0.2172 |
5080-50-2; |
7045767 |
||
| oleoylcarnitine |
|
0.83 |
0.3694 |
|
|
||
|
Fatty alcohol, long chain |
1-octadecanol |
D01924 |
1.01 |
0.8513 |
112-92-5; |
8221 |
|
|
Glycerolipid metabolism |
choline phosphate |
C00588 |
0.97 |
0.4914 |
72556-74-2; |
1014 |
|
| ethanolamine |
C00189 |
1.10 |
0.4703 |
141-43-5; |
|
||
| phosphoethanolamine |
C00346 |
1.06 |
0.5812 |
1071-23-4; |
52,323,241,015 |
||
| glycerol |
C00116 |
0.97 |
0.6203 |
56-81-5; |
753 |
||
| glycerol 3-phosphate (G3P) |
C00093 |
0.98 |
0.6926 |
29849-82-9; |
754 |
||
| glycerophosphorylcholine (GPC) |
C00670 |
0.96 |
0.9071 |
28319-77-9; |
657272 |
||
| cytidine 5'-diphosphocholine |
C00307 |
1.25 |
0.0583 |
33818-15-4; |
13805 |
||
|
Inositol metabolism |
myo-inositol |
C00137 |
0.94 |
0.0882 |
87-89-8; |
|
|
| chiro-inositol |
|
0.77 |
0.1568 |
643-12-9; |
|
||
| inositol 1-phosphate (I1P) |
|
1.01 |
0.8432 |
106032-59-1; |
|
||
| scyllo-inositol |
C06153 |
0.90 |
0.1635 |
488-59-5; |
|
||
|
Ketone bodies |
3-hydroxybutyrate (BHBA) |
C01089 |
1.23 |
0.2197 |
625-72-9; |
441 |
|
|
Lysolipid |
1-palmitoylglycerophosphoethanolamine |
|
1.12 |
0.8591 |
|
9547069 |
|
| 2-palmitoylglycerophosphoethanolamine* |
|
0.83 |
0.1926 |
|
|
||
| 1-stearoylglycerophosphoethanolamine |
|
1.20 |
0.7882 |
69747-55-3; |
9547068 |
||
| 1-oleoylglycerophosphoethanolamine |
|
1.14 |
0.8654 |
|
9547071 |
||
| 2-oleoylglycerophosphoethanolamine* |
|
1.07 |
0.9602 |
|
|
||
| 1-arachidonoylglycerophosphoethanolamine* |
|
1.06 |
0.8488 |
|
|
||
| 2-arachidonoylglycerophosphoethanolamine* |
|
0.45 |
0.2213 |
|
|
||
| 2-docosahexaenoylglycerophosphoethanolamine* |
|
0.48 |
0.3141 |
|
|
||
| 1-palmitoylglycerophosphocholine |
|
0.47 |
0.1450 |
17364-16-8; |
86554 |
||
| 2-palmitoylglycerophosphocholine* |
|
0.59 |
0.2106 |
|
|
||
| 1-stearoylglycerophosphocholine |
|
0.51 |
0.1452 |
19420-57-6; |
497299 |
||
| 2-stearoylglycerophosphocholine* |
|
1.00 |
|
|
10208382 |
||
| 1-oleoylglycerophosphocholine |
|
0.56 |
0.1923 |
19420-56-5; |
16081932 |
||
| 2-oleoylglycerophosphocholine* |
|
0.65 |
0.3441 |
|
|
||
| 1-arachidonoylglycerophosphocholine* |
C05208 |
1.00 |
|
|
|
||
| 2-arachidonoylglycerophosphocholine* |
|
0.89 |
0.4485 |
|
|
||
| 1-docosahexaenoylglycerophosphocholine* |
|
1.00 |
|
|
|
||
| 2-docosahexaenoylglycerophosphocholine* |
|
0.86 |
0.4614 |
|
|
||
| 1-palmitoylglycerophosphoinositol* |
|
0.85 |
0.2160 |
|
|
||
| 1-stearoylglycerophosphoinositol |
|
0.77 |
0.1315 |
|
|
||
| 1-arachidonoylglycerophosphoinositol* |
|
0.87 |
0.3521 |
|
|
||
| 1-oleoylglycerophosphoserine |
|
0.92 |
0.6515 |
|
9547099 |
||
| 2-oleoylglycerophosphoserine* |
|
0.80 |
0.1921 |
|
|
||
| 1-palmitoylplasmenylethanolamine* |
|
1.23 |
0.5225 |
|
|
||
|
Monoacylglycerol |
1-palmitoylglycerol (1-monopalmitin) |
|
0.83 |
0.1685 |
542-44-9; |
14900 |
|
| 1-stearoylglycerol (1-monostearin) |
D01947 |
0.92 |
0.3625 |
123-94-4; |
24699 |
||
| 2-stearoylglycerol (2-monostearin) |
|
0.75 |
0.1774 |
621-61-4; |
79075 |
||
| 1-oleoylglycerol (1-monoolein) |
|
0.80 |
0.1139 |
111-03-5; |
5283468 |
||
| 2-oleoylglycerol (2-monoolein) |
|
0.59 |
0.0769 |
3443-84-3; |
5319879 |
||
|
Sphingolipid |
sphingosine |
C00319 |
0.71 |
0.3009 |
123-78-4; |
5353955 |
|
| palmitoyl sphingomyelin |
|
0.84 |
0.1297 |
|
9939941 |
||
| stearoyl sphingomyelin |
C00550 |
1.07 |
0.2147 |
85187-10-6;85187-10-6; |
6453725 |
||
|
Mevalonate metabolism |
3-hydroxy-3-methylglutarate |
C03761 |
1.07 |
0.4426 |
503-49-1; |
5459993 |
|
| Sterol/Steroid | cholesterol |
C00187 |
1.00 |
0.9987 |
57-88-5; |
6432564 |
|
| 7-alpha-hydroxycholesterol |
C03594 |
1.24 |
0.2998 |
566-27-8; |
107722 |
||
| 7-beta-hydroxycholesterol |
C03594 |
1.11 |
0.2969 |
566-27-8; |
473141 |
||
| 24(S)-hydroxycholesterol |
C13550 |
0.94 |
0.5728 |
2140-46-7; |
|
||
| corticosterone | C02140 | 0.59 | 0.2402 | 50-22-6; | 5753 |